Background: Pneumonia is a leading cause of hospitalization and death among older adults, re-flecting both patient vulnerability and the quality of acute care. However, evidence from Latin America remains limited. Objective: to examine the association between frailty level assessed using the HFRS and in-hospital mortality among older adults hospitalized with community-acquired pneumonia (CAP). Methods: We conducted a retrospective cohort study using the Chilean National Health Fund (Fondo Nacional de Salud, FONASA) database, including patients aged ≥60 years hospitalized with CAP (ICD-10 codes J12–J18) between 2019 and 2024. Variables analyzed included age, sex, frailty level assessed by the Hospital Frailty Risk Score (HFRS), comorbidity burden (Charlson Comorbidity Index), Diagnosis-Related Group (DRG) severity level, and relative weight. Survival was analyzed using Kaplan–Meier curves and log-rank tests. Multivariable Cox proportional hazards models estimated adjusted hazard ratios (HR) with 95% confidence intervals (CI). Results: The cohort comprised 58,040 patients (51.2% women). Overall, in-hospital mortality was 19.3%. Independent predictors of mortality included ad-vanced age (≥90 years: HR = 2.41; 95% CI: 2.27–2.56), male sex (HR = 1.10; 95% CI: 1.06–1.14), high frailty risk (HR = 1.57; 95% CI: 1.47–1.68), and greater DRG severity (per level: HR = 1.66; 95% CI: 1.58–1.73). The Charlson Comorbidity Index lost significance after adjustment. Conclu-sions: Frailty emerged as a strong and independent determinant of in-hospital mortality in old-er adults with CAP. Systematic frailty assessment combined with comorbidity indices could im-prove risk stratification and guide more personalized, evidence-based clinical management in acute care settings.

Authors:
Yeny Concha Cisterna, Santo Tomás University, Chile
Eduardo Guzmán-Muñoz, santo Tomas University, Chile

About the Presenter(s)
Yeny Fabiola Concha Cisternas, Director of the Master in Clinical Gerontology. I focus on aging, frailty and physical function. My current project examines clinical, nutritional and psychosocial indicators of sarcopenia.

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