To assess the association between sarcopenia indicators and alpha-diversity in the fecal of hemodialysis patients. Methods: This was a cross-sectional study. Maintenance hemodialysis patients who were older than 20 years old and have 3 times in-center hemodialysis treatment/week were included. The criteria of low muscle mass were according to the diagnosis guideline from Asian Working Group on Sarcopenia (AWGS) 2019: the appendicular skeletal muscle mass was measured by bioelectrical impedance analysis and appendicular skeletal muscle mass index (ASMI) less than 7.0 kg/height (m)2 for men and 5.7 kg/height (m)2 for women. The alpha-diversity of stool sample was assessed by 16S rRNA gene amplified sequencing method. Clinical Trial Registry: NCT05809219 and NCT05809219; https://clinicaltrials.gov Results: The completed data of twenty-eight hemodialysis patients was collected. The average age was 61.1 years old, and 15 of the participants were male. Nineteen of the participants have low muscle mass, and the mean ASMI was 6.4 ± 2.0 kg/m2. Hemodialysis patients with low muscle mass had significantly better alpha-diversity, comparing with those without low muscle mass (6.0 ± 0.7 vs. 5.1 ± 0.8, P=0.017, respectively). The odds ratio of of alpha-diversity and low muscle mass was 0.201 (95% confidence interval=0.045-0.902). Neither the concentration of serum interleukin-6 nor of C reactive protein were not significantly different between participants with or without low muscle mass. Conclusion: In this study, adult patients with hemodialysis treatment with low muscle mass had better alpha-diversity in the fecal. The future studies with more participants and longer observation period are needed.

Authors:
Pei-Yu Wu, China Medical University, Taiwan
Hyey-Liang Kuo, China Medical University Hospital, Taiwan
Jung-Piao Tsao, China Medical University, Taiwan
Shwu-Huey Yang, Taipei Medical University, Taiwan
FangYu Zhung, China Medical University, Taiwan
Wei-Ren Li, China Medical University, Taiwan

About the Presenter(s)
Dr.Pei-Yu Wu is currently an Assistant Professor at Department of Nutrition, China Medical University, Taiwan.

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