Cuproptosis, a recently identified cell death mechanism, has gained attention for its association with diverse diseases. However, the genetic interplay between cuproptosis and ovarian aging remains largely unexplored. This study aims to fill this gap by analyzing datasets related to ovarian aging and cuproptosis. To elucidate FDX1's role, spatial transcriptome analyses were conducted in the ovaries of both young and aged female mice. Comprehensive bioinformatics analyses, facilitated by R software, revealed FDX1 as a potential cuproptosis-related gene with implications for ovarian aging. Clinical infertility biopsies were also examined to validate these findings, demonstrating consistent results in elderly infertile patients. Furthermore, pharmacogenomic analyses of ovarian cell lines explored the intricate association between FDX1 expression levels and sensitivity to specific small molecule drugs. Spatial transcriptome analyses unveiled a significant reduction in FDX1 expression in aging ovaries, supported by consistent findings in biopsies from elderly infertile patients. Pharmacogenomic investigations indicated that modulating FDX1 could influence drug responses in ovarian-related therapies. This study pioneers the identification of FDX1 as a cuproptosis-related gene linked to ovarian aging. These findings not only contribute to understanding the mechanisms of ovarian aging but also position FDX1 as a potential diagnostic biomarker and therapeutic target. Further research may establish FDX1's pivotal role in advancing precision medicine and therapies for ovarian-related conditions.

Authors:
Chia-Jung Li, Kaohsiung Veterans General Hospital, Taiwan
Kuan-Hao Tsui, Kaohsiung Veterans General Hospital, Taiwan

About the Presenter(s)
Dr Chia-Jung Li is a University Assistant Professor/Lecturer at Kaohsiung Veterans General Hospital in Taiwan

See this presentation on the full schedule – Tuesday Schedule

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